Job Summary:

The Hsieh Laboratory at University of Colorado Anschutz Medical Campus (CU-AMC) is looking for a full-time postdoctoral fellow in the field of Inborn Errors of Immunity (IEI) for an NIH-funded project focused on understanding COVID vaccine-elicited immune response in B cell immunodeficiency.

We are a laboratory that studies 1) "classic autoimmunity" (i.e., lupus) and 2) inborn errors of immunity (IEI) that present with autoimmunity/inflammation. Using primary human samples, in vitro cell lines, and CRISPR/Cas engineered mouse models of human disease, we identify and study novel IEI to dissect the molecular and cellular mechanisms that govern self-tolerance and anti-microbial immunity and provide critical insights for effective therapies in immunodeficiency, malignancy, and autoimmunity/inflammation.

Key Responsibilities:

Research (80%)

• Pursue research goals established by the principal investigator and the fellow. Responsible for all aspects of planning, developing, operating, recording, and reporting of assigned research projects. Participates actively in designing, developing, and executing a wide variety of experimental investigations with considerable independence on a day-to-day basis. The fellow will regularly work with the principal investigator to make progress on these objectives.
• Has or acquires the skills necessary to accomplish research goals including, but not limited to, techniques in molecular biology (DNA and RNA manipulation, cloning, PCR), biochemistry (expression and purification of monoclonal antibodies and other recombinant proteins, SPR, BLI), virology (virus infection, cell culture, neutralization assays), immunology (flow cytometry, cell sorting, ELISA, ELISPOT), and in vivo mouse work (injection, infections, blood collection, organ harvesting, mouse genetics/breeding).
• Collaborate with and teach other researchers to accomplish major research goals
• Maintains a neat and orderly laboratory workspace, including data collection and organization, maintaining laboratory equipment, and generally being a good lab citizen.
• Participates regularly in departmental seminars, journal clubs, research in progress presentations, and lab meetings.

Research Publications and Grant Applications (10%)

• Analyzes and prepares research data for presentation at scientific meetings, for publication, and for use in grant applications.
• Assists the principal investigator with writing and editing of scientific manuscripts and grant applications.
• Meets regularly with principal investigator to present research progress, review research data, troubleshoot, and plan future experiments.
• Presents data in more formal settings including lab meetings, departmental research in progress presentations, journal clubs, and national and international conferences, meetings, and workshops.

Supervision and Training (10%)

• Trains and supervises laboratory student workers, medical, or graduate students, professional research assistants, or other laboratory personnel, as assigned by the principal investigator.
• Acts as a technical and scientific advisor to laboratory members and/or collaborating scientists regarding areas of expertise.

Why Join Us:

The University of Colorado offers a comprehensive benefits package that includes health insurance, life insurance, retirement plans, tuition benefits, ECO pass, paid time off - vacation, sick, and holidays and more. To see what benefits are available, please visit: https://www.cu.edu/employee-services/benefits-wellness.

Diversity and Equity:

The University of Colorado Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities, persons within the LGBTQ+ community and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

Qualifications:

Minimum Qualifications:

Applicants must meet minimum qualifications at the time of hire.

• All requirements of graduation from an accredited college or university with a Ph.D., M.D, D.V.M., or equivalent doctoral level degree in microbiology, immunology, molecular biology, biochemistry, or a related field before the starting date for this position. Candidates in the final stages of completing their doctoral level degree are eligible to apply.
• High-quality first-author publications in the field of immunology

Preferred Qualifications:

• Experience with human immunology research in autoimmunity and/or IEI
• Published work in a peer-reviewed journal.
• Demonstrated skills in problem solving, and in working collaboratively and effectively with other members of a research team.
• Demonstrated effectiveness in communicating orally and in writing.
• Demonstrated ability to work independently.
• Experience working with viruses, animal handling and experimentation, and processing of human blood and tissues.
• Experience with basic immunology techniques including flow cytometry, ELISAs, and ELISPOT.
• Experience in or knowledge of computational approaches.

How to Apply:

For full consideration, please submit the following document(s):

1. A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position
2. Curriculum vitae / Resume
3. Five professional references including name, address, phone number (mobile number if appropriate), and email address

Applications are accepted electronically ONLY at www.cu.edu/cu-careers.

Screening of Applications Begins:

Screening begins on 01/10/2023

Anticipated Pay Range:

The starting salary range (or hiring range) for this position has been established as HIRING RANGE:

$54,840 - $66,600

The above salary range (or hiring range) represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting. This position is not eligible for overtime compensation unless it is non-exempt.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.

Total Compensation Calculator: http://www.cu.edu/node/153125

ADA Statement:

The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at hr.adacoordinator@ucdenver.edu.

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

Vaccination Statement:

CU Anschutz strongly encourages vaccination against the COVID-19 virus and other vaccine preventable diseases. If you work, visit, or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz, you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work, visit, or volunteer, respectively. In addition, if you work in certain research areas or perform certain safety sensitive job duties, you must enroll in the occupational health medical surveillance program.